Rate-Based Robust Adaptive Performance Tracking Control Of Network Flows

Network flow control methods have been studied for years to ensure the efficient usage of network resources. By adopting a representation reminiscent of the slidingsurface representation, this work explores a highly adaptive network flow control strategy. The rate-based network flow control scheme is investigated through a novel model description in the matrix notation, and guaranteed to be stable under mildassumptions

An interferon regulatory factor-like binding element restricts Xmyf-5 expression in the posterior somites during Xenopus myogenesis

AbstractThe expression of myf-5, a key component of myogenic regulatory genes, declines progressively in mature somitic cells during vertebrate myogenesis. Little is known about how this down-regulation takes place. Here we provide evidence that an interferon regulatory factor binding element (IRF element) within the Xenopus myf-5 promoter is responsible for the elimination of myf-5 transcription in mature somitic mesoderm of Xenopus embryos. We show that this IRF element mediates the down-regulation of Xmyf-5 transcription in gastrula embryos, and can specifically interact with nuclear proteins of early neurula. Moreover, deletion of this IRF element results in the anterior expansion of reporter gene transcripts within somitic mesoderm in transgenic embryos. Our results, therefore, provide insight into how the negative control of Xmyf-5 expression takes place

Membrane transporters in drug development

Membrane transporters can be major determinants of the pharmacokinetic, safety and efficacy profiles of drugs. This presents several key questions for drug development, including which transporters are clinically important in drug absorption and disposition, and which in vitro methods are suitable for studying drug interactions with these transporters. In addition, what criteria should trigger follow-up clinical studies, and which clinical studies should be conducted if needed. In this article, we provide the recommendations of the International Transporter Consortium on these issues, and present decision trees that are intended to help guide clinical studies on the currently recognized most important drug transporter interactions. The recommendations are generally intended to support clinical development and filing of a new drug application. Overall, it is advised that the timing of transporter investigations should be driven by efficacy, safety and clinical trial enrolment questions (for example, exclusion and inclusion criteria), as well as a need for further understanding of the absorption, distribution, metabolism and excretion properties of the drug molecule, and information required for drug labelling. © 2010 Macmillan Publishers Limited

The cosmic ray test of MRPCs for the BESIII ETOF upgrade

In order to improve the particle identification capability of the Beijing Spectrometer III (BESIII),t is proposed to upgrade the current endcap time-of-flight (ETOF) detector with multi-gap resistive plate chamber (MRPC) technology. Aiming at extending ETOF overall time resolution better than 100ps, the whole system including MRPC detectors, new-designed Front End Electronics (FEE), CLOCK module, fast control boards and time to digital modules (TDIG), was built up and operated online 3 months under the cosmic ray. The main purposes of cosmic ray test are checking the detectors' construction quality, testing the joint operation of all instruments and guaranteeing the performance of the system. The results imply MRPC time resolution better than 100$ps$, efficiency is about 98$\%$ and the noise rate of strip is lower than 1$Hz/$($scm^{2}$) at normal threshold range, the details are discussed and analyzed specifically in this paper. The test indicates that the whole ETOF system would work well and satisfy the requirements of upgrade

Non-invasive and accurate risk evaluation of cerebrovascular disease using retinal fundus photo based on deep learning

BackgroundCerebrovascular disease (CeVD) is a prominent contributor to global mortality and profound disability. Extensive research has unveiled a connection between CeVD and retinal microvascular abnormalities. Nonetheless, manual analysis of fundus images remains a laborious and time-consuming task. Consequently, our objective is to develop a risk prediction model that utilizes retinal fundus photo to noninvasively and accurately assess cerebrovascular risks.Materials and methodsTo leverage retinal fundus photo for CeVD risk evaluation, we proposed a novel model called Efficient Attention which combines the convolutional neural network with attention mechanism. This combination aims to reinforce the salient features present in fundus photos, consequently improving the accuracy and effectiveness of cerebrovascular risk assessment.ResultOur proposed model demonstrates notable advancements compared to the conventional ResNet and Efficient-Net architectures. The accuracy (ACC) of our model is 0.834 ± 0.03, surpassing Efficient-Net by a margin of 3.6%. Additionally, our model exhibits an improved area under the receiver operating characteristic curve (AUC) of 0.904 ± 0.02, surpassing other methods by a margin of 2.2%.ConclusionThis paper provides compelling evidence that Efficient-Attention methods can serve as effective and accurate tool for cerebrovascular risk. The results of the study strongly support the notion that retinal fundus photo holds great potential as a reliable predictor of CeVD, which offers a noninvasive, convenient and low-cost solution for large scale screening of CeVD

Perceptions of the health risk from hot days and the cooling effect of urban green spaces: a case study in Xi’an, China

BackgroundHot days are one of the typical threats to human health and sustainable cities. The exploration of residents’ perceptions of thermal environment and its mitigation measures will support the health risk prevention.MethodsA survey with a combination of closed-ended and open-ended questions was conducted in July 2021 among 13 urban parks in Xi’an City, China. With the help of ANOVA and ordinal logistic regression, this study investigated the influencing factors both on residents’ health risk perception of hot days and their perception of the effect of urban ecological landscape on reducing the thermal risk. The relationship between health risk perception and residents’ needs of urban ecological construction was also explored.ResultsAccording to 325 valid questionnaires, the male-female ratio of respondents was found to be 1:0.87, young people aged 18-29 (26.46%), the retirees (27.08%) and the ones with undergraduate education (33.23%) were, relatively, the largest groups. The results show that 92.31% of the respondents believed that their daily lives were under the influence of hot days. Housing types, occupation, cooling equipment at work, and outdoor working hours all had a significant impact on their high temperature perceptions. The proportion of respondents who were under a huge health risk and sought medical treatment due to hot days was 30.16% and 44.92%, respectively. Women were 18.52 and 2.33 times more likely to suffer health threats and experience discomforts than men. Furthermore, 73.23% of the respondents believed that the urban ecological landscapes in Xi’an had an enhanced cooling effect in recent years. Compared with the morphological characteristics, residents’ recognition of the restriction of landscape’s area on its cooling effect was higher, and the residence duration showed a significant influence.ConclusionThe cooling effect of green spaces and water effectively resisted urban thermal threats, and residents’ needs of the urban ecological landscapes was associated with their health risk perceptions of hot days. In the future, it is necessary to promote the early warning of hot days, meanwhile, the optimization of landscape patterns of green infrastructures should be implemented in urban planning for the purposes of residents’ health risk prevention

Functional and Transcriptional Characterization of Human Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Myocardial Infarction

BACKGROUND: Differentiation of human embryonic stem cells into endothelial cells (hESC-ECs) has the potential to provide an unlimited source of cells for novel transplantation therapies of ischemic diseases by supporting angiogenesis and vasculogenesis. However, the endothelial differentiation efficiency of the conventional embryoid body (EB) method is low while the 2-dimensional method of co-culturing with mouse embryonic fibroblasts (MEFs) require animal product, both of which can limit the future clinical application of hESC-ECs. Moreover, to fully understand the beneficial effects of stem cell therapy, investigators must be able to track the functional biology and physiology of transplanted cells in living subjects over time. METHODOLOGY: In this study, we developed an extracellular matrix (ECM) culture system for increasing endothelial differentiation and free from contaminating animal cells. We investigated the transcriptional changes that occur during endothelial differentiation of hESCs using whole genome microarray, and compared to human umbilical vein endothelial cells (HUVECs). We also showed functional vascular formation by hESC-ECs in a mouse dorsal window model. Moreover, our study is the first so far to transplant hESC-ECs in a myocardial infarction model and monitor cell fate using molecular imaging methods. CONCLUSION: Taken together, we report a more efficient method for derivation of hESC-ECs that express appropriate patterns of endothelial genes, form functional vessels in vivo, and improve cardiac function. These studies suggest that hESC-ECs may provide a novel therapy for ischemic heart disease in the future